Key:YWXYYJSYQOXTPL-SLPGGIOYSA-N YIsosorbide mononitrate, sold under many brand names, is a medication used for (angina),. It can be used both to treat and to prevent heart related chest pain, however is generally less preferred than. It is taken by mouth.Common side effects include headache, blurry vision, and skin flushing. Serious side effects may include especially if also exposed to such as. Use is not recommended in. It is believed to work by relaxing within.It was patented in 1971 and approved for medical use in 1981.
It is available as a. A month supply in the United Kingdom costs the about one £ per month as of 2019. In the United States the wholesale cost of this amount is about US$4.30. In 2016 it was the 101st most prescribed medication in the United States with more than 7 million prescriptions. Contents.Medical uses Isosorbide mononitrate is a -class drug used for the prevention of angina pectoris.Adverse effects The following adverse effects have been reported in studies with isosorbide mononitrate:Very common: Headache predominates (up to 30%) necessitating withdrawal of 2 to 3% of patients, but the incidence reduces rapidly as treatment continues.Common: Tiredness, sleep disturbances (6%) and gastrointestinal disturbances (6%) have been reported during clinical trials with isosorbide mononitrate modified-release tablets, but at a frequency no greater than for placebo. (4 to 5%), poor appetite (2.5%), nausea (1%).Adverse effects associated with the clinical use of the drug are as expected with all nitrate preparations.
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They occur mainly in the early stages of treatment.Hypotension (4%) with symptoms such as dizziness and nausea (1%) have been reported. In general, these symptoms disappear during long-term treatment.Other reactions that have been reported with isosorbide mononitrate modified-release tablets include, vomiting, diarrhoea, and heartburn.Interactions.
(Viagra). Concomitant administration of isosorbide mononitrate and sildenafil (Viagra) or other phosphodiesterase inhibitors (Tadalafil and Udenafil) can potentiate the vasodilatory effect of isosorbide mononitrate with the potential result of serious side-effects such as. Life-threatening hypotension may also occur. Therefore, sildenafil should not be given to patients already receiving isosorbide mononitrate therapy. Sulfhydryl-containing compounds. The metabolism of organic nitrates to nitric oxide is dependent on the presence of sulfhydryl groups in the muscle.
The combination of oral and a single dose of sustained-release isosorbide mononitrate 60 mg significantly prolonged the total exercise time in patients with angina pectoris and angiographically proven significant coronary artery disease, when compared with isosorbide mononitrate alone. Concomitant administration of other exogenous sources of sulfhydryl groups such as and may produce a similar interaction. Phenylalkylamine calcium antagonists. The addition of a of the type, such as 75 mg, has been shown to further improve left ventricular functional parameters when given in combination with isosorbide mononitrate in a sustained-release formulation. The addition of isosorbide mononitrate to propranolol treatment in patients with and caused a marked fall in portal pressure, a reduction in hepatic blood flow, cardiac output and mean arterial blood pressure, but no additional change in blood flow. The additional effect of isosorbide mononitrate was especially evident in patients whose portal pressure was not reduced by propranolol. (general).
Marked symptomatic has been reported when calcium antagonists and organic nitrates were used in combination. Dose adjustments of either class of agent may be necessary.Brand names It is sold in the US by under the trade name Monoket, also sold in the US under the name Imdur, and marketed in the UK under the trade names: Isotard, Monosorb, Chemydur. In India, this drug is available under the brand names of Ismo, Imdur,Isonorm, Monotrate, Solotrate, and Monit.
In it is occasionally used under the brand names Monocinque and Pektrol. In Australia, this drug is available under the brand name Duride.References.
This article is based largely on the Wikipedia article on.Emperor: Battle for Dune is a Dune computer game, released by Westwood Studios in 2001. It is based in 's science fiction Dune universe. Informally, it is known as Dune III.It is the third real-time strategy game set in the Dune universe, following its predecessors,.
While Dune II was a totally distinct story to that of, and Dune 2000 was a remake of Dune II, Emperor is a direct sequel to the previous games. In particular, it is a sequel to Dune 2000, carrying on from where it left off, with several of the characters and actors returning.Like Dune 2000 and many of the other Westwood games that came before it, Emperor features cut scenes filmed with live actors and produced with professional-class visual effects. Contents StoryEmperor is set shortly after the of Dune 2000. Emperor has been killed by his, Lady, and the has been thrown into chaos.The has presented the three remaining Houses (the same as those in the previous games:, and ) with a unique challenge: a on the planet.